Assoc. Prof. Ayça Sayı Yazgan
Academic Positions
2013-contd
Associate Prof, Istanbul Technical University
Department of Molecular Biology and Genetics
2010-2013
Assistant Prof, Istanbul Technical University
Department of Molecular Biology and Genetics
2006-2010
Postdoctoral fellow, University of Zurich, Switzerland
Working in the group of Prof. Anne Mueller.
Education
2001 – 2006 Ph.D. student, University of Basel, Switzerland
Worked as a PhD student initially at Friedrich Miescher Institute
Novartis Foundation (2001-2003) and subsequently in Institute of Cell Biology at ETH Zurich (2003-2006)
Worked under supervision of Prof. Wilhelm Krek.
1999 – 2001 M.Sc., Department of Molecular Biology and Genetics, Bilkent University, Ankara, Turkey
Worked under supervision of Prof.Tayfun Ozcelik
1997 – 2001 B. Sc., Department of Biomedical Sciences, Cerrahpasa Medical Faculty, Istanbul University, Turkey
Projects
Supported by | Name of the Project | Worked as |
UBS Foundation, Switzerland, 2007-2009 | The immune response to Helicobacter pylori infection and its role in gastric carcinogenesis | Researcher |
Desiree & Yde’s Foundation, Switzerland, 2007-2010 | The immune response to Helicobacter pylori infection and its role in gastric carcinogenesis | Researcherl |
Stiftung zur Krebsbekaempfung, Switzerland, | Characterization of the regulatory role of T- and B- cell subsets in the control of Helicobacter – induced gastric preneoplasia | Researcher |
İTÜ Scientific Research Foundation, Turkey, 2010 | Investigating the interaction between Helicobacter pylori -infected gastric epithelial cells and B cells in molecular level | Project Leader |
Tübitak Project, Turkey, 2011-2014 | The molecular characterization of Helicobacter specific regulatory B cells | Project Leader |
İTÜ Scientific Research Foundation, Turkey, 2011-2014 | The interaction between H.pylori infection and the response of T helper cells (Th1, Th2, Th17) in infected human gastric biopsies | Project Leader |
Tübitak Project, Turkey, 2013-2016 | Investigation of the functional interactions between Helicobacter-activated regulatory B cells with innate and cell-mediated immune system | Project Leader |
Tübitak Project, Turkey, 2015-2016 | Gene expression profiling of Helicobacter activated regulatory B cells | Project Leader |
Tübitak Project, Turkey, 2014-2017 | Investigation on the Effects of Mechanical Forces on Endothel Cells Behaviour by Using Microfludics Systems in the domain of Mechanobiology | Researcher |
Memberships
• International Society for Interferon and Cytokine Research
• Turkish Society of Immunology (General Secretary since 2013)
• Turkish Medical Biology & Genetics Organization
• Molecular Biology Organization (MolbioTurk)
• Molecular Cancer Research Organization (MOKAD)
• The European Association for Cancer Research (EACR)
• Society for Leukocyte Biology (SLB)
• American Society for Microbiology (ASM)
Publications
Articles
- S. Oktem Okullu, A. Tiftikci, M. Saruc, B. Cicek, E. Vardareli, N. Tozun, T. Kocagoz, U. Sezerman, AS Yavuz,A. Sayi Yazgan “Multiplex-PCR-Based Screening and Computational Modeling of Virulence Factors and T-Cell Mediated Immunity in Helicobacter pylori Infections for Accurate Clinical Diagnosis”, PLoS One, August 2015, Vol 10, no 8, e0136212
- R. Caliskan, A. Sayi Yazgan, H. B. Tokman, E. Sofyali, Y. Z. Erzin, O. Akgul, A. Kurt, F. Kalayci, T. Ziver, P. Yuksel, K. Bal, B. Kocazeybek “The cytokine response in THP-1 (monocyte) and HL-60 (neutrophil-differentiated) cells infected with different genotypes of Helicobacter pylori strains”, Turkish Journal of Gastroenterology, July 2015, Vol 26, no 4, 297-303,
- M. Zuvin, N. Mansur, Z. S. Birol, L. Trabzon, A. Sayi Yazgan “Human breast
cancer cell enrichment by Dean flow driven microfluidic channels”, Microsystem Technologies, January 2015 - I. Hitzler, E. Kohler, D. B. Engler, A. Sayi Yazgan, A. Müller “The role of Th cell subsets in the control of Helicobacter infections and in T-cell driven gastric immunopathology”, Frontiers in Mucosal Immunity, June 2012, Vol 3, no 142, 1-8,
- I. Hitzler, A. Sayi, E. Kohler, D. B. Engler, K. N. Koch, W. D. Hardt, A. Müller “Caspase-1 has both pro-inflammatory and regulatory properties in Helicobacter infections, which are differentially mediated by its substrates IL-1β and IL-18” Journal of Immunology April 2012; Vol 188, no. 8, 3594-602
- A. Sayi, E. Kohler, I. Toller, R. A. Flavell, W. Mueller, A. Roers, A. Mueller “ TLR-2–Activated B Cells Suppress Helicobacter-Induced Preneoplastic Gastric Immunopathology by Inducing T Regulatory-1” Journal of Immunology Jan 2011; Vol. 186, no. 2, 878-890
- I.Toller, I.Hitzler, A.Sayi, A.Mueller (2010). “Prostaglandin E2 prevents Helicobacter-induced gastric preneoplasia and facilitates persistent infection in a mouse model” Gastroenterology, April 2010, Vol 138:issue 4, 1455-1467
- A.Mueller, A.Sayi, I.Hitzler, “Protective and pathogenic functions of T-cells are inseparable during the Helicobacter-host interaction”,Discovery Medicine, published on September 2009
- A.Sayi, E.Kohler, I.Hitzler, Isabelle Arnold, Reto Schwendener, Hubert Rehrauer, A.Mueller (2009) “The CD4+ T-cell-mediated Interferon-gamma response to Helicobacter infection is essential for clearance and determines gastric cancer risk”, Journal of Immunology, 2009 June; 182: 7085-7101.
- Topcu M, Akyerli C, Sayi A, Toruner GA, Kocoglu SR, Cimbis M, Ozcelik T. Somatic mosaicism for a MECP2 mutation associated with classic Rett syndrome in a boy. Eur J Hum Genet. 2002 Jan;10(1):77-81.